Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: Convergent synthesis of the CDEFG-Ring system

Kazushi Sato, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

(Chemical Equation Presented) A convergent synthetic route to the CDEFG-ring system of gambieric acids, potent antifungal polycyclic ether marine natural products, has been developed. The present synthesis features convergent union of the CD- and G-rings through esterification, formation of the E-ring as a lactone form, stereoselective allylation to set the C26 stereocenter, and ring-closing metathesis reaction to construct the nine-membered F-ring.

Original languageEnglish
Pages (from-to)2441-2444
Number of pages4
JournalOrganic letters
Volume7
Issue number12
DOIs
Publication statusPublished - 2005 Jun 9

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: Convergent synthesis of the CDEFG-Ring system'. Together they form a unique fingerprint.

Cite this