Abstract
(Chemical Equation Presented) A solid approach to ethereal rings: Key features of a convergent synthesis of the nonacyclic polyether skeleton of gambieric acids A and C include the connection of the BCD and GHIJ ring systems by esterification, the construction of the E ring in the form of a lactone, a stereoselective allylation to establish the C26 stereocenter, and the formation of the F ring by ring-closing metathesis (see scheme; Bn = benzyl, NAP = 2-naphthylmethyl).
| Original language | English |
|---|---|
| Pages (from-to) | 2518-2522 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 46 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2007 Jun 29 |
Keywords
- Cyclization
- Metathesis
- Natural products
- Polyethers
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)