Abstract
(Chemical Equation Presented) A solid approach to ethereal rings: Key features of a convergent synthesis of the nonacyclic polyether skeleton of gambieric acids A and C include the connection of the BCD and GHIJ ring systems by esterification, the construction of the E ring in the form of a lactone, a stereoselective allylation to establish the C26 stereocenter, and the formation of the F ring by ring-closing metathesis (see scheme; Bn = benzyl, NAP = 2-naphthylmethyl).
Original language | English |
---|---|
Pages (from-to) | 2518-2522 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2007 Jun 29 |
Keywords
- Cyclization
- Metathesis
- Natural products
- Polyethers
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)