Studies toward the Total Synthesis of Caribbean Ciguatoxin C-CTX-1: Synthesis of the LMN-Ring Fragment through Reductive Olefin Cross-Coupling

Makoto Sasaki, Kotaro Iwasaki, Keisuke Arai

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Synthesis of the LMN-ring fragment of Caribbean ciguatoxin C-CTX-1, the principal causative toxin for ciguatera fish poisoning around the Caribbean Sea areas, is described. The key feature of the synthesis is the stereoselective introduction of an angular methyl group on the sterically encumbered seven-membered M-ring by the application of a hydrogen atom transfer-based reductive olefin coupling.

Original languageEnglish
Pages (from-to)7163-7166
Number of pages4
JournalOrganic letters
Volume20
Issue number22
DOIs
Publication statusPublished - 2018 Nov 16

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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