Studies toward the enantioselective synthesis of neurymenolide A: Construction of the macrocyclic core via Claisen rearrangement

Masahiro Masuda, Natsuki Sakurai, Yusuke Ogura, Tetsuji Murase, Tsuneomi Kawasaki, Shohei Aiba, Naoki Mori, Hidenori Watanabe, Hirosato Takikawa

Research output: Contribution to journalArticlepeer-review

Abstract

Neurymenolides, α-pyrone macrolides isolated from the Fijian red alga Neurymenia fraxinifolia, are anti-methicillin-resistant Staphylococcus aureus and anti-vancomycin-resistant Enterococcus faecium compounds. In this study, the macrocyclic core of neurymenolide A was constructed in an enantioselective manner by employing Claisen rearrangement as the key step.

Original languageEnglish
Article number151825
JournalTetrahedron Letters
Volume61
Issue number18
DOIs
Publication statusPublished - 2020 Apr 30
Externally publishedYes

Keywords

  • Claisen rearrangement
  • Macrolides
  • Neurymenolides
  • α-Pyrone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Studies toward the enantioselective synthesis of neurymenolide A: Construction of the macrocyclic core via Claisen rearrangement'. Together they form a unique fingerprint.

Cite this