Abstract
Neurymenolides, α-pyrone macrolides isolated from the Fijian red alga Neurymenia fraxinifolia, are anti-methicillin-resistant Staphylococcus aureus and anti-vancomycin-resistant Enterococcus faecium compounds. In this study, the macrocyclic core of neurymenolide A was constructed in an enantioselective manner by employing Claisen rearrangement as the key step.
Original language | English |
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Article number | 151825 |
Journal | Tetrahedron Letters |
Volume | 61 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2020 Apr 30 |
Externally published | Yes |
Keywords
- Claisen rearrangement
- Macrolides
- Neurymenolides
- α-Pyrone
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry