Studies toward the enantioselective synthesis of neurymenolide A: Construction of the macrocyclic core via Claisen rearrangement

Masahiro Masuda; Natsuki Sakurai; Yusuke Ogura; Tetsuji Murase; Tsuneomi Kawasaki; Shohei Aiba; Naoki Mori; Hidenori Watanabe; Hirosato Takikawa

doi:10.1016/j.tetlet.2020.151825

Studies toward the enantioselective synthesis of neurymenolide A: Construction of the macrocyclic core via Claisen rearrangement

Masahiro Masuda, Natsuki Sakurai, Yusuke Ogura, Tetsuji Murase, Tsuneomi Kawasaki, Shohei Aiba, Naoki Mori, Hidenori Watanabe, Hirosato Takikawa

Research output: Contribution to journal › Article › peer-review

Abstract

Neurymenolides, α-pyrone macrolides isolated from the Fijian red alga Neurymenia fraxinifolia, are anti-methicillin-resistant Staphylococcus aureus and anti-vancomycin-resistant Enterococcus faecium compounds. In this study, the macrocyclic core of neurymenolide A was constructed in an enantioselective manner by employing Claisen rearrangement as the key step.

Original language	English
Article number	151825
Journal	Tetrahedron Letters
Volume	61
Issue number	18
DOIs	https://doi.org/10.1016/j.tetlet.2020.151825
Publication status	Published - 2020 Apr 30
Externally published	Yes

Keywords

Claisen rearrangement
Macrolides
Neurymenolides
α-Pyrone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Studies toward the enantioselective synthesis of neurymenolide A : Construction of the macrocyclic core via Claisen rearrangement. / Masuda, Masahiro; Sakurai, Natsuki; Ogura, Yusuke; Murase, Tetsuji; Kawasaki, Tsuneomi; Aiba, Shohei; Mori, Naoki; Watanabe, Hidenori; Takikawa, Hirosato.

In: Tetrahedron Letters, Vol. 61, No. 18, 151825, 30.04.2020.

Research output: Contribution to journal › Article › peer-review

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AU - Murase, Tetsuji

AU - Kawasaki, Tsuneomi

AU - Aiba, Shohei

AU - Mori, Naoki

AU - Watanabe, Hidenori

AU - Takikawa, Hirosato

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