Studies Relating to the Synthesis of the Immunosuppressive Agent FK-506: Coupling of Fragments via a Stereoselective Trisubstituted Olefin Forming Reaction Sequence

A. Brian Jones, Masahiko Yamaguchi, Arthur Patten, Samuel J. Danishefsky, John A. Ragan, David B. Smith, Stuart L. Schreiber

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The asymmetric synthesis of FK-506 fragments is reported that illustrates a method for the preparation of one of the trisubstituted olefins within the macrolide.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalJournal of Organic Chemistry
Volume54
Issue number1
DOIs
Publication statusPublished - 1989 Jan 1

ASJC Scopus subject areas

  • Organic Chemistry

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