Studies on Uricosuric Diuretics: III: Substituted l,3-Dioxolo[4,5-/]-l,2-benzisoxazole-6-carboxylic Acids and l^-DioxoloJ^S-g^-l^-benzisoxazole-T-carboxylic Acids1)

Haruhiko Sato, Takashi Dan, Etsuro Onuma, Haruko Tanaka, Bunya Aoki, Hiroshi Koga

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A series of substituted 1,3-dioxolo[4,5-/]-l, 2-benzisoxazole-6-carboxylic acids 13 and l,3-dioxolo[4,5-#]-l,2-benzisoxazole-7-carboxylic acids 14 were synthesized and evaluated for diuretic and uricosuric activities in rats. Most of the benzisoxazole derivatives 13 and 14 showed potent diuretic activities. Moderate uricosuric activities were also found in 14a, 14b, and 14f.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • 2-benzisoxazole-6-carboxylic acid l
  • 2-benzisoxazole-7-carboxylic acid
  • 3-dioxolo[4
  • 3-dioxolo[4
  • 5-/]-l
  • 5-g]-l
  • diuretic activity uricosuric activity l

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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