Studies on Uricosuric Diuretics: I: Syntheses and Activities of Xanthonyloxyacetic Acids and Dihy-drofuroxanthone-2-carboxylic Acids

Haruhiko Sato, Takashi Dan, Etsuro Onuma, Haruko Tanaka, Hiroshi Koga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A series of substituted xanthonyloxyacetic acids (5 and 6), l,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-A]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.

Original languageEnglish
Pages (from-to)1266-1277
Number of pages12
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number5
DOIs
Publication statusPublished - 1990 Jan 1

Keywords

  • 2,3-dihydrofuro[3
  • 2-6]xanthone-2-carboxylic acid diuretic activity
  • uricosuric activity
  • xanthonyloxyacetic acid 1.2-dihydrofuro[2.3-c]xanthone-2-carboxylic acid:

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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