TY - JOUR
T1 - Studies on Uricosuric Diuretics
T2 - I: Syntheses and Activities of Xanthonyloxyacetic Acids and Dihy-drofuroxanthone-2-carboxylic Acids
AU - Sato, Haruhiko
AU - Dan, Takashi
AU - Onuma, Etsuro
AU - Tanaka, Haruko
AU - Koga, Hiroshi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - A series of substituted xanthonyloxyacetic acids (5 and 6), l,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-A]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.
AB - A series of substituted xanthonyloxyacetic acids (5 and 6), l,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-A]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.
KW - 2,3-dihydrofuro[3
KW - 2-6]xanthone-2-carboxylic acid diuretic activity
KW - uricosuric activity
KW - xanthonyloxyacetic acid 1.2-dihydrofuro[2.3-c]xanthone-2-carboxylic acid:
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U2 - 10.1248/cpb.38.1266
DO - 10.1248/cpb.38.1266
M3 - Article
C2 - 2393951
AN - SCOPUS:0025003392
SN - 0009-2363
VL - 38
SP - 1266
EP - 1277
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 5
ER -