TY - JOUR
T1 - Studies on the mechanism of drug distribution in tissues
AU - Terasaki, T.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - The importance to elucidate the mechanisms of drug distribution in tissues has been discussed in this review. By considering several factors such as tissue binding, plasma binding, membrane permeability and tissue interstitial fluid space, the tissue distribution states of drug have been characterized based on the biochemical and pharmacokinetic studies. These physiological pharmacokinetic analyses have been applied to evaluate the determinant factors of inter-organ, drug to drug, interspecies or age related changes of tissue distribution of drug. The mechanisms of membrane permeability of drug which could play the most important role to regulate the drug distribution have been discussed. The drug distribution to the brain is strictly restricted by the function of the blood-brain barrier (BBB). The drug transport mechanisms at he BBB have been discussed. Especially, the role of carrier-mediated and absorptive-mediated transport systems at the BBB has been focused on.
AB - The importance to elucidate the mechanisms of drug distribution in tissues has been discussed in this review. By considering several factors such as tissue binding, plasma binding, membrane permeability and tissue interstitial fluid space, the tissue distribution states of drug have been characterized based on the biochemical and pharmacokinetic studies. These physiological pharmacokinetic analyses have been applied to evaluate the determinant factors of inter-organ, drug to drug, interspecies or age related changes of tissue distribution of drug. The mechanisms of membrane permeability of drug which could play the most important role to regulate the drug distribution have been discussed. The drug distribution to the brain is strictly restricted by the function of the blood-brain barrier (BBB). The drug transport mechanisms at he BBB have been discussed. Especially, the role of carrier-mediated and absorptive-mediated transport systems at the BBB has been focused on.
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U2 - 10.1248/yakushi1947.112.12_887
DO - 10.1248/yakushi1947.112.12_887
M3 - Review article
C2 - 1294715
AN - SCOPUS:0027077881
VL - 112
SP - 887
EP - 905
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 12
ER -