Abstract
A new triterpenoid, 12-ursene-3β, 11 α-diol 3-O-palmitate (1), has been isolated from the rhizomes and roots of Gentiana lutea, together with the artificial diene derivative, 9 (11), 12-ursadien-3β-ol 3-O-palmitate (1a) and five known compounds (3 - 7). Their structures were established on the basis of spectral analysis. In addition, (±)-gentiolactone [(±)-2], isolated from this plant, was successfully separated into its enantiomers [(+)-2, (-)-2] for the first time, and the absolute configurations at C-9 of (+)-2, (-)-2 were assigned as S and R, respectively, from the optical rotations and the circular dichroism (CD) spectral data.
| Original language | English |
|---|---|
| Pages (from-to) | 885-887 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 51 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2003 Jul |
Keywords
- (R)-(-)-gentiolactone
- (S)-(+)-gentiolactone
- Gentiana lutea
- Gentianaceae
- Triterpenoid
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Kakuda, R., Machida, K., Yaoita, Y., Kikuchi, M., & Kikuchi, M. (2003). Studies on the constituents of Gentiana species. II. A new triterpenoid, and (S)-(+)- and (R)-(-)-gentiolactones from Gentiana lutea. Chemical and Pharmaceutical Bulletin, 51(7), 885-887. https://doi.org/10.1248/cpb.51.885