TY - JOUR
T1 - Studies on Pyrimidine Derivatives. XXIX. Synthesis of Pyrimidines fused with Five-membered Heterocycles by Cross-coupling of 5-Iodopyrimidines with Phenylacetylene and Styrene
AU - Sakamoto, Takao
AU - Kondo, Yoshinori
AU - Yamanaka, Hiroshi
PY - 1982/1/1
Y1 - 1982/1/1
N2 - 2,4-Dimethyl-6-phenyl-furo- and -thieno-[2,3-d]-pyrimidine were synthesized by cross-couping of 2,6-dimethyl-5-iodopyrimidines with phenylacetylene in the presence of palladium catalyst, followed by cyclization of the resulting phenylethynylpyrimidines. 2,4-Dimethyl-6-phenyl[2,3-d]pyrimidine was also synthesized by the thermal decomposition of 4-azido-2,6-dimethyl-5-styrylpyrimidine, which was obtained from the 4-chloro derivative.
AB - 2,4-Dimethyl-6-phenyl-furo- and -thieno-[2,3-d]-pyrimidine were synthesized by cross-couping of 2,6-dimethyl-5-iodopyrimidines with phenylacetylene in the presence of palladium catalyst, followed by cyclization of the resulting phenylethynylpyrimidines. 2,4-Dimethyl-6-phenyl[2,3-d]pyrimidine was also synthesized by the thermal decomposition of 4-azido-2,6-dimethyl-5-styrylpyrimidine, which was obtained from the 4-chloro derivative.
KW - 5-iodopyrimidine
KW - cross-coupling reaction
KW - furo[2,3-d]pyrimidine
KW - palladium catalyst
KW - phenylacetylene
KW - pyrrolo[2,3-d]pyrimidine
KW - styrene
KW - thieno[2,3-d]pyrimidine
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U2 - 10.1248/cpb.30.2417
DO - 10.1248/cpb.30.2417
M3 - Article
AN - SCOPUS:0020458716
VL - 30
SP - 2417
EP - 2420
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 7
ER -