Studies on Pyrimidine Derivatives. XLI. Palladium-Catalyzed Cross-Coupling Reaction of Halopyrimidines with Aryl- and Vinyltributylstannanes

Yoshinori Kondo, Ryo Watanabe, Takao Sakamoto, Hiroshi Yamanaka

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The arylation of 2-, 4-, and 5-halopyrimidines with aryltributylstannanes in the presence of dichlorobis-(triphenylphosphine)palladium was investigated with successful results. The reaction can be expanded to the synthesis of 2-, 4-, and 5-vinylpyrimidines with generality. The site-selectivity of the reaction for 4,5-dihalopyrimidines is also described.

Original languageEnglish
Pages (from-to)2814-2816
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume37
Issue number10
DOIs
Publication statusPublished - 1989

Keywords

  • arylpyrimidine
  • aryltributylstannane
  • halopyrimidine
  • palladium catalyzed reaction
  • site-selectivity
  • vinyl-pyrimidine
  • vinyltributylstannane

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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