Studies on multiple-resistant Staphylococcus aureus. (VII). In vitro combined effects of arbekacin plus cefuzonam against respiratory isolates of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Akira Watanabe, Satoru Shoji, Tohru Higuchi, Matsuhisa Inoue

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The antibiotic sensitivity of 51 strains of methicillin-resistant Staphylococcus aureus (MRSA) and 15 strains of Pseudomanas aeruginosa was determined, and the in vitro combined effects on them of arbakacin plus cefuzonam and other combinations were evaluated. In terms of activity against MRSA, vancomycin was in first place, followed by arbekacin, minocycline, imipenem, cefuzonam, fosfomycin and methicillin, in decreasing order. In regard to activity against P. aeruginosa, imipenem was in first place, followed by cefsulodin, ceftazidime, aztreonam, ceftizoxime, piperacillin and cefuzonam, in decreasing order. The in vitro combined effects of arbakacin plus cefuzonam and vancomycin plus cefuzonam on MRSA were synergistic, while those of arbekacin plus minocycline and vancomycin plus minocycline were somewhat antagonistic. Combinations of cefuzonam plus arbakacin, or vancomycin, or imipenem, or fosfomycin were partially synergistic against P.aeruginosa. Combination of less than 1 MIC each of arbakacin and cefuzonam yielded a synergistic killing effect against not only single cultures of MRSA and P. aeruginosa, respectively, but againsta mixed culture of both microbes. The above findings suggest that the combined regimen of arbakacin plus cefuzonam is useful for the treatment of MRSA infections, especially respiratory infections, which include many cases of polymicrobial infections caused by MRSA and P. aeruginosa, despite the fact that the rates of penetration of anti-microbials into disease foci in such infections is less than that in normal tissues.

    Original languageEnglish
    Pages (from-to)19-25
    Number of pages7
    JournalChemotherapy
    Volume42
    Issue number1
    DOIs
    Publication statusPublished - 1994 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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