Studies on multiple-resistant staphylococcus aureus. (V). In vitro combined effect of cefuzonam plus minocycline against methicillin-resistant staphylococcus aureus (MRSA)

Akira Watanabe, Kohtaro Ohizumi, Seiichi Aonuma, Reiko Ono, Yoshihiro Honda, Yutaka Tokue, Naoto Kitamura, Satoru Shoji, Kiyoshi Konno

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    11 Citations (Scopus)

    Abstract

    The in vitro combined effect of cefuzonam (CZON) plus minocycline (MINO) against 403 strains of Staphylococcus aureus (152 MRSA and 251 MSSA strains) isolated in the Tohoku district of Japan in 1987, was examined by a checkerboard microbroth dilution method using the Dynatech MIC-2000. The mean FIC (fractional inhibitory concentration) index of this combination for all 403 strains of S. aureus was 0.652, being 0429 for MRS A, and 0.764 for MSSA. This combination was more effective against highly-resistant MRSA strains (MIC>25μg/ml), as revealed by the mean FIC index of 0.405, than against moderately-resistant MRSA strains (MIC=12.5 and 25 μg/ml), whose mean FIC index was 0.485. It was also more effective against cefuzonam-resistant than against cefuzonam-sensitive MRSA strains: the mean FIC index being 0.388 for those strains whose MIC exceeded 6.25 μg/ml; 0.520 for those whose MIC was 6.25, 3.13 or 1.56μg/ml; and 0.625 for those whose MIC was below 1.56μg/ml. On the other hand, when the MIC of minocycline against MRSA was high, the mean FIC index of the combination was not markedly decreased by the addition of cefuzonam. Based on our results, we conclude that minocycline made a more significant contribution to this combination Than did cefuzonam.

    Original languageEnglish
    Pages (from-to)131-136
    Number of pages6
    JournalChemotherapy
    Volume37
    Issue number2
    DOIs
    Publication statusPublished - 1989 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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