Studies on multiple-resistant staphylococcus aureus. (IV). Difference in incidence of methicillin-resistant staphylococcus aureus (MRSA) among institutions, departments and specimens

Akira Watanabe, Kohtaro Ohizumi, Seiichi Aonuma, Reiko Ono, Yoshihiro Honda, Yutaka Tokue, Naoto Kitamura, Satoru Shoji, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    The sensitivity to methicillin (DMPPC) and cefazolin (CEZ) of 378 strains of Staphylococcus aureus isolated in 12 institutions in the Tohoku district of Japan in 1987, was examined by a microbroth dilution method using the Dynatech MIC-2000. The incidence of methicillin-resistant strains (MIC≥12.5μg/ml) of S. aureus (MRSA) was 34.4%(130/378), and that of cefazolin-resistant strains (MIC≥12.5 μg/ml) 32.5%(123/378). Of 130 MRSA strains, 107 were resistant also to cefazolin. There was astatistically significant specimen-to-specimen difference in the incidence of MRS A, which was higher in aspirated sputum, blood and urine than in expectorated sputum, pus, otorrhea and throat swab. The incidence of MRSA among institutions was found to vary between 0% and 75%. This difference was statistically significant. MRSA incidence among institutions with more and those with less than 500 inpatients was 44.3% and 14.4%, respectively, the difference being again statistically significant. The incidence of MRSA among departments was found to vary between 12.1% and 75.0%. The incidence of MRSA in urology, neurosurgery and general surgery departments was higher than in otorhinolaryngology and respiratory departments. The above results suggest that the increase in the incidence of MRSA can, for the most part, be ascribed to hospital infection.

    Original languageEnglish
    Pages (from-to)125-130
    Number of pages6
    JournalChemotherapy
    Volume37
    Issue number2
    DOIs
    Publication statusPublished - 1989 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

    Fingerprint Dive into the research topics of 'Studies on multiple-resistant staphylococcus aureus. (IV). Difference in incidence of methicillin-resistant staphylococcus aureus (MRSA) among institutions, departments and specimens'. Together they form a unique fingerprint.

    Cite this