Studies on in vitro activity of t-1220 and clinical experience in the treatment of respiratory infections

Akira Watanabe; Masako Sasaki; Yukinor Yonemoto; Sonok Saito

doi:10.11250/chemotherapy1953.25.967

Studies on in vitro activity of t-1220 and clinical experience in the treatment of respiratory infections

Akira Watanabe, Masako Sasaki, Yukinor Yonemoto, Sonok Saito

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Antimicrobial activity of T-1220, a new penicillin derivative, was studied. The drug showed lower levels of MICs than those of Sulbenicillin against clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa. Clinical evaluation of the drug was made by intravenous administration to a total 7 cases with secondary respiratory tract infections with gram negative bacilli. In 2 cases the drug was withdrawn because of the onset of chill and fever during the drip infusion in a case and of eruption in the other.

Original language	English
Pages (from-to)	967-972
Number of pages	6
Journal	Chemotherapy
Volume	25
Issue number	5
DOIs	https://doi.org/10.11250/chemotherapy1953.25.967
Publication status	Published - 1977 Jan 1

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.11250/chemotherapy1953.25.967

Cite this

@article{4dfdf9f54c914eb0853569c7fd26a013,

title = "Studies on in vitro activity of t-1220 and clinical experience in the treatment of respiratory infections",

abstract = "Antimicrobial activity of T-1220, a new penicillin derivative, was studied. The drug showed lower levels of MICs than those of Sulbenicillin against clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa. Clinical evaluation of the drug was made by intravenous administration to a total 7 cases with secondary respiratory tract infections with gram negative bacilli. In 2 cases the drug was withdrawn because of the onset of chill and fever during the drip infusion in a case and of eruption in the other.",

author = "Akira Watanabe and Masako Sasaki and Yukinor Yonemoto and Sonok Saito",

year = "1977",

month = jan,

day = "1",

doi = "10.11250/chemotherapy1953.25.967",

language = "English",

volume = "25",

pages = "967--972",

journal = "CHEMOTHERAPY",

issn = "0009-3165",

number = "5",

}

TY - JOUR

T1 - Studies on in vitro activity of t-1220 and clinical experience in the treatment of respiratory infections

AU - Watanabe, Akira

AU - Sasaki, Masako

AU - Yonemoto, Yukinor

AU - Saito, Sonok

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Antimicrobial activity of T-1220, a new penicillin derivative, was studied. The drug showed lower levels of MICs than those of Sulbenicillin against clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa. Clinical evaluation of the drug was made by intravenous administration to a total 7 cases with secondary respiratory tract infections with gram negative bacilli. In 2 cases the drug was withdrawn because of the onset of chill and fever during the drip infusion in a case and of eruption in the other.

AB - Antimicrobial activity of T-1220, a new penicillin derivative, was studied. The drug showed lower levels of MICs than those of Sulbenicillin against clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa. Clinical evaluation of the drug was made by intravenous administration to a total 7 cases with secondary respiratory tract infections with gram negative bacilli. In 2 cases the drug was withdrawn because of the onset of chill and fever during the drip infusion in a case and of eruption in the other.

UR - http://www.scopus.com/inward/record.url?scp=0017403677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017403677&partnerID=8YFLogxK

U2 - 10.11250/chemotherapy1953.25.967

DO - 10.11250/chemotherapy1953.25.967

M3 - Article

AN - SCOPUS:0017403677

SN - 0009-3165

VL - 25

SP - 967

EP - 972

JO - CHEMOTHERAPY

JF - CHEMOTHERAPY

IS - 5

ER -

Studies on in vitro activity of t-1220 and clinical experience in the treatment of respiratory infections

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this