Studies on in vitro activity of t-1220 and clinical experience in the treatment of respiratory infections

Akira Watanabe, Masako Sasaki, Yukinor Yonemoto, Sonok Saito

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Antimicrobial activity of T-1220, a new penicillin derivative, was studied. The drug showed lower levels of MICs than those of Sulbenicillin against clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa. Clinical evaluation of the drug was made by intravenous administration to a total 7 cases with secondary respiratory tract infections with gram negative bacilli. In 2 cases the drug was withdrawn because of the onset of chill and fever during the drip infusion in a case and of eruption in the other.

    Original languageEnglish
    Pages (from-to)967-972
    Number of pages6
    JournalChemotherapy
    Volume25
    Issue number5
    DOIs
    Publication statusPublished - 1977 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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