Studies on constituent of 'KAKO-BUSHI-MATSU'

Miwa Matsui, Yoshie Sato, Hideo Bando, Mitsuo Murayama, Takaomi Osawa, Tsutomu Miura, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A pyrrole derivative, 4-(2-formyl-5-hydroxymethylpyrrol-1-yl)-butyric acid, was isolated from processed Aconitum roots, 'KAKO-BUSHI-MATSU'. Its content was higher in 'KAKO-BUSHI-MATSU' than in dried Aconitum roots, and it was considered that the compound was produced by the heating procedure used for the preparation of the medicine. The compound increased the peripheral blood flow in mouse, and we propose a new processing mechanism involved in Maillard reaction on preparation of the crude drug, bushi.

Original languageEnglish
Pages (from-to)232-235
Number of pages4
JournalNatural Medicines
Issue number3
Publication statusPublished - 1998


  • Aconitum species
  • Maillard reaction
  • Peripheral blood flow
  • Pyrrole derivative

ASJC Scopus subject areas

  • Molecular Medicine


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