Studies on combination of antibiotics (V)

Seiichi Aonuma; Fumio Ariji; Kikuo Onuma; Akira Watanabe; Masako Sasaki; Kotaro Oizumi; Kiyoshi Konno

doi:10.11250/chemotherapy1953.30.1461

Studies on combination of antibiotics (V)

Seiichi Aonuma, Fumio Ariji, Kikuo Onuma, Akira Watanabe, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In vitro combined activity of cephalothin (CET) and amikacin (AMK), cefazolin (CEZ) and dibekacin (DKB), cefmetazole (CMZ) and DKB against K. pneumoniae PCI 602 was examined. Bactericidal activity against K. pneumoniae PCI 602 was enhanced by combination of cephems. (CEPs) and aminoglycosides (AGs). When bacilli were treated for two hours with CEPs (1/2 MIC) plus AGs (1/2MIC), the viable cell count decreased markedly and the colony-forming unit was found to be 1/1,000 of the initial inoculum. Morphological changes of K. pneumoniae PCI 602 were observed by electron microscopy, when bacilli were treated with CEZ and DKB alone and in combination. Combination If CEZ (1/2 MIC) and DKB (1/2 MIC) caused marked destruction of the bacilli.

Original language	English
Pages (from-to)	1461-1464
Number of pages	4
Journal	Chemotherapy
Volume	30
Issue number	12
DOIs	https://doi.org/10.11250/chemotherapy1953.30.1461
Publication status	Published - 1982 Jan 1

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11250/chemotherapy1953.30.1461

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AU - Ariji, Fumio

AU - Onuma, Kikuo

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AU - Sasaki, Masako

AU - Oizumi, Kotaro

AU - Konno, Kiyoshi

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Studies on combination of antibiotics (V)

Abstract

ASJC Scopus subject areas

UN SDGs

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