Structured triglycerides containing medium-chain fatty acids and linoleic acid differently influence clearance rate in serum of triglycerides in rats

Taiji Kishi, Octavio Carvajal, Hiroko Tomoyori, Ikuo Ikeda, Michihiro Sugano, Katsumi Imaizumi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We examined clearance rates in serum of lymph lipids collected from rats fed a diet containing one of four types of structured triglycerides containing linoleic and medium-chain fatty acids, 1) sn-1 (3) medium-chain fatty acids-sn-2 linoleic acid (MLM), 2) interesterified MLM (iMLM), 3) sn-2 mediumchain fatty acids-sn-1 (3) linoleic acid (LML), and 4) interesterified LML (iLML). Rats with permanent cannulation of thoracic duct were fed a diet containing one of the structured triglycerides and then, thoracic duct lymph was collected. The lymph was injected into the right superior vena cava in rats fed the same diet for a week. Half-life of triglyceride was significantly longer in rats injected the lymph originated from rats fed LML compared to the other groups. Half-life of retinyl palmitate, a marker of chylomicron remnant, tended to be longer in the LML group. These observations suggest that the structural differences in triglycerides containing medium-chain fatty acids and linoleic acid can alter the rate of lipid clearance in serum of rats.

Original languageEnglish
Pages (from-to)1343-1351
Number of pages9
JournalNutrition Research
Volume22
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Keywords

  • Chylomicrons
  • Linoleic acid
  • Lymph
  • Medium-chain fatty acids
  • Retinyl palmitate
  • Structured triglycerides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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