Structure formation and catalytic activity of DNA dissolved in organic solvents

Hiroshi Abe, Naoko Abe, Aya Shibata, Keiji Ito, Yoshiyuki Tanaka, Mika Ito, Hisao Saneyoshi, Satoshi Shuto, Yoshihiro Ito

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Equal-opportunity dissolver: By attaching polyethylene glycol at its 5' end, DNA (PEG-DNA) can be solubilized in various organic solvents and was shown to form G-quadruplexes by CD spectroscopy. A complex containing iron(III) protoporphyrin IX (hemin) and G-quadruplex-forming PEG-DNA catalyzed an oxidative reaction in methanol (see scheme).

Original languageEnglish
Pages (from-to)6475-6479
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number26
DOIs
Publication statusPublished - 2012 Jun 25

Keywords

  • DNA
  • G-quadruplexes
  • nucleic acids
  • porphyrinoids
  • structure-activity relationships

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Abe, H., Abe, N., Shibata, A., Ito, K., Tanaka, Y., Ito, M., Saneyoshi, H., Shuto, S., & Ito, Y. (2012). Structure formation and catalytic activity of DNA dissolved in organic solvents. Angewandte Chemie - International Edition, 51(26), 6475-6479. https://doi.org/10.1002/anie.201201111