Structure formation and catalytic activity of DNA dissolved in organic solvents

Hiroshi Abe; Naoko Abe; Aya Shibata; Keiji Ito; Yoshiyuki Tanaka; Mika Ito; Hisao Saneyoshi; Satoshi Shuto; Yoshihiro Ito

doi:10.1002/anie.201201111

Structure formation and catalytic activity of DNA dissolved in organic solvents

Hiroshi Abe, Naoko Abe, Aya Shibata, Keiji Ito, Yoshiyuki Tanaka, Mika Ito, Hisao Saneyoshi, Satoshi Shuto, Yoshihiro Ito

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Equal-opportunity dissolver: By attaching polyethylene glycol at its 5' end, DNA (PEG-DNA) can be solubilized in various organic solvents and was shown to form G-quadruplexes by CD spectroscopy. A complex containing iron(III) protoporphyrin IX (hemin) and G-quadruplex-forming PEG-DNA catalyzed an oxidative reaction in methanol (see scheme).

Original language	English
Pages (from-to)	6475-6479
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	26
DOIs	https://doi.org/10.1002/anie.201201111
Publication status	Published - 2012 Jun 25

Keywords

DNA
G-quadruplexes
nucleic acids
porphyrinoids
structure-activity relationships

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201201111

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Structure formation and catalytic activity of DNA dissolved in organic solvents. / Abe, Hiroshi; Abe, Naoko; Shibata, Aya; Ito, Keiji; Tanaka, Yoshiyuki; Ito, Mika; Saneyoshi, Hisao; Shuto, Satoshi; Ito, Yoshihiro.

In: Angewandte Chemie - International Edition, Vol. 51, No. 26, 25.06.2012, p. 6475-6479.

Research output: Contribution to journal › Article › peer-review

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AU - Abe, Naoko

AU - Shibata, Aya

AU - Ito, Keiji

AU - Tanaka, Yoshiyuki

AU - Ito, Mika

AU - Saneyoshi, Hisao

AU - Shuto, Satoshi

AU - Ito, Yoshihiro

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AB - Equal-opportunity dissolver: By attaching polyethylene glycol at its 5' end, DNA (PEG-DNA) can be solubilized in various organic solvents and was shown to form G-quadruplexes by CD spectroscopy. A complex containing iron(III) protoporphyrin IX (hemin) and G-quadruplex-forming PEG-DNA catalyzed an oxidative reaction in methanol (see scheme).

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KW - G-quadruplexes

KW - nucleic acids

KW - porphyrinoids

KW - structure-activity relationships

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Structure formation and catalytic activity of DNA dissolved in organic solvents

Abstract

Keywords

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