Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1)

Y. Furukawa, S. Nakatsuru, A. Nagafuchi, S. Tsukita, T. Muto, Y. Nakamura, A. Horii

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We have isolated the human α-catenin gene (CTNNA1), which encodes a cadherin-associated protein, and have determined its primary structure and chromosomal localization. The transcript of CTNNA1 is 3.4 kb long and consists of 16 coding exons encoding 906 amino acids and at least one 5' noncoding exon. The 102-kDa predicted protein is the same size as the murine homolog, and the amino acid sequences of the two proteins are 99.2% homologous. Analysis by reverse transcription-PCR revealed that this gene is expressed ubiquitously in normal tissues. It was mapped to chromosome band 5q31 by fluorescent in situ hybridization.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalCytogenetics and Cell Genetics
Volume65
Issue number1-2
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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    Furukawa, Y., Nakatsuru, S., Nagafuchi, A., Tsukita, S., Muto, T., Nakamura, Y., & Horii, A. (1993). Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1). Cytogenetics and Cell Genetics, 65(1-2), 74-78.