Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

Makoto Ishikawa; Yu Sawada; Takeshi Yoshitomi

doi:10.1016/j.exer.2015.02.017

Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

Makoto Ishikawa, Yu Sawada, Takeshi Yoshitomi

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions.

Original language	English
Pages (from-to)	3-18
Number of pages	16
Journal	Experimental Eye Research
Volume	133
DOIs	https://doi.org/10.1016/j.exer.2015.02.017
Publication status	Published - 2015 Apr 1
Externally published	Yes

Keywords

Age-related macular degeneration
Growth factors
Inherited retinal degenerative disorders
Interphotoreceptor matrix
Interphotoreceptor retinoid binding protein
Photoreceptor cell
Proteoglycans
Retina

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/j.exer.2015.02.017

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title = "Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells",

abstract = "The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions.",

keywords = "Age-related macular degeneration, Growth factors, Inherited retinal degenerative disorders, Interphotoreceptor matrix, Interphotoreceptor retinoid binding protein, Photoreceptor cell, Proteoglycans, Retina",

author = "Makoto Ishikawa and Yu Sawada and Takeshi Yoshitomi",

note = "Funding Information: This work was supported in part by JSPS KAKENHI Grant No. 24592666 to M.I. Publisher Copyright: {\textcopyright} 2015 The Authors.",

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doi = "10.1016/j.exer.2015.02.017",

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AU - Sawada, Yu

AU - Yoshitomi, Takeshi

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KW - Growth factors

KW - Inherited retinal degenerative disorders

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KW - Proteoglycans

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Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

Abstract

Keywords

ASJC Scopus subject areas

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