Structure and function of nanogels by hydrophobized cluster dextrin

Yavoi Ozawa; Yuya Sasaki; Nobuyuki Morimoto; Kimio Kurita; Shin Ichi Kitamura; Kazunari Akiyoshi

Structure and function of nanogels by hydrophobized cluster dextrin

Yavoi Ozawa, Yuya Sasaki, Nobuyuki Morimoto, Kimio Kurita, Shin Ichi Kitamura, Kazunari Akiyoshi

Research output: Contribution to conference › Paper › peer-review

Abstract

We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5(CH-CDex1.5) and 2.4(CH-CDex2.4) determined by 1H-NMR. Solution properties of CH-CDex in water were investigated by DLS and MALS. CH-CDex formed self-associates consisting of 2-3(CH-CDex1.5) and 3-4(CH-CDex2.4) CH-CDex macromolecules, and the particle size (diameter) was 29.4 nm(CH-CDex1.5) and 24.6nm(CH-CDex2.4) by DLS.

Original language	English
Pages	2022
Number of pages	1
Publication status	Published - 2006
Externally published	Yes
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26

Other

Other	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

Keywords

Cluster dextrin
Hydrophobically modified polysaccharides
Nanogels
Self-assembly

ASJC Scopus subject areas

Engineering(all)

Cite this

@conference{2a4de80dbe634daebd32b6489867a916,

title = "Structure and function of nanogels by hydrophobized cluster dextrin",

abstract = "We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5(CH-CDex1.5) and 2.4(CH-CDex2.4) determined by 1H-NMR. Solution properties of CH-CDex in water were investigated by DLS and MALS. CH-CDex formed self-associates consisting of 2-3(CH-CDex1.5) and 3-4(CH-CDex2.4) CH-CDex macromolecules, and the particle size (diameter) was 29.4 nm(CH-CDex1.5) and 24.6nm(CH-CDex2.4) by DLS.",

keywords = "Cluster dextrin, Hydrophobically modified polysaccharides, Nanogels, Self-assembly",

author = "Yavoi Ozawa and Yuya Sasaki and Nobuyuki Morimoto and Kimio Kurita and Kitamura, {Shin Ichi} and Kazunari Akiyoshi",

year = "2006",

language = "English",

pages = "2022",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

}

TY - CONF

T1 - Structure and function of nanogels by hydrophobized cluster dextrin

AU - Ozawa, Yavoi

AU - Sasaki, Yuya

AU - Morimoto, Nobuyuki

AU - Kurita, Kimio

AU - Kitamura, Shin Ichi

AU - Akiyoshi, Kazunari

PY - 2006

Y1 - 2006

N2 - We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5(CH-CDex1.5) and 2.4(CH-CDex2.4) determined by 1H-NMR. Solution properties of CH-CDex in water were investigated by DLS and MALS. CH-CDex formed self-associates consisting of 2-3(CH-CDex1.5) and 3-4(CH-CDex2.4) CH-CDex macromolecules, and the particle size (diameter) was 29.4 nm(CH-CDex1.5) and 24.6nm(CH-CDex2.4) by DLS.

AB - We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5(CH-CDex1.5) and 2.4(CH-CDex2.4) determined by 1H-NMR. Solution properties of CH-CDex in water were investigated by DLS and MALS. CH-CDex formed self-associates consisting of 2-3(CH-CDex1.5) and 3-4(CH-CDex2.4) CH-CDex macromolecules, and the particle size (diameter) was 29.4 nm(CH-CDex1.5) and 24.6nm(CH-CDex2.4) by DLS.

KW - Cluster dextrin

KW - Hydrophobically modified polysaccharides

KW - Nanogels

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=33749829586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749829586&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749829586

SP - 2022

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Structure and function of nanogels by hydrophobized cluster dextrin

Abstract

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Keywords

ASJC Scopus subject areas

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