Structure and function of nanogels by hydrophobized cluster dextrin

Yavoi Ozawa, Yuya Sasaki, Nobuyuki Morimoto, Kimio Kurita, Shin Ichi Kitamura, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review


We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5(CH-CDex1.5) and 2.4(CH-CDex2.4) determined by 1H-NMR. Solution properties of CH-CDex in water were investigated by DLS and MALS. CH-CDex formed self-associates consisting of 2-3(CH-CDex1.5) and 3-4(CH-CDex2.4) CH-CDex macromolecules, and the particle size (diameter) was 29.4 nm(CH-CDex1.5) and 24.6nm(CH-CDex2.4) by DLS.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26


Other55th SPSJ Annual Meeting


  • Cluster dextrin
  • Hydrophobically modified polysaccharides
  • Nanogels
  • Self-assembly

ASJC Scopus subject areas

  • Engineering(all)


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