Structure-activity relationship studies of gymnocin-A

Chihiro Tsukano, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The structural elements required for cytotoxicity of gymnocin-A, a polycyclic ether isolated from the red tide-forming dinoflagellate, Karenia mikimotoi, were investigated by the total synthesis and evaluation of the structural analogues. The results of the structure-activity relationship studies indicated that the α,β-unsaturated aldehyde functionality of the side chain as well as the molecular length were needed for exhibiting the cytotoxicity of gymnocin-A.

Original languageEnglish
Pages (from-to)6803-6807
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number38
DOIs
Publication statusPublished - 2006 Sep 18

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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