Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA

Naoki Umezawa, Yuhei Horai, Yuki Imamura, Makoto Kawakubo, Mariko Nakahira, Nobuki Kato, Akira Muramatsu, Yuko Yoshikawa, Kenichi Yoshikawa, Tsunehiko Higuchi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A versatile solid-phase approach based on peptide chemistry was used to construct four classes of structurally diverse polyamines with modified backbones: linear, partially constrained, branched, and cyclic. Their effects on DNA duplex stability and structure were examined. The polyamines showed distinct activities, thus highlighting the importance of polyamine backbone structure. Interestingly, the rank order of polyamine ability for DNA compaction was different to that for their effects on circular dichroism and melting temperature, thus indicating that these polyamines have distinct effects on secondary and higher-order structures of DNA.

Original languageEnglish
Pages (from-to)1811-1819
Number of pages9
JournalChemBioChem
Volume16
Issue number12
DOIs
Publication statusPublished - 2015 Aug 1
Externally publishedYes

Keywords

  • DNA structures
  • amines
  • peptides
  • single-molecule studies
  • solid-phase synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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