Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression

Teigo Asai, Takashi Yamamoto, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Isao Fujii, Katsuya Gomi, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Epigenetic manipulation of gene expression in Chaetomium indicum using a HDAC inhibitor led to the isolation of structurally diverse chaetophenols, and 3, 4 and 5 bear unprecedented polycyclic skeletons. The expression of two silent genes (pksCH-1 and pksCH-2) for nonreducing PKSs involved in chaetophenol biosynthesis was associated with an increase of histone acetylation level. The heterologous gene expression study in Aspergillus oryzae revealed pksCH-2 to be the NR-PKS gene for 8.

Original languageEnglish
Pages (from-to)3346-3349
Number of pages4
JournalOrganic letters
Volume15
Issue number13
DOIs
Publication statusPublished - 2013 Jul 5

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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