Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1

Ichiro Takahashi, Shozo Kotani, Haruhiko Takada, Teisuo Shiba, Shoichi Kusumoto

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A variety of compounds, synthetic, semisynthetic or bacterial, which corre-sponds to structural components of endotoxic lipopolysaccharides (LPS) and bacterial cell wall peptidoglycans were studied for their activity to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production by macrophages and activated the human complement cascade, which may lead to the IL-1 production by monocytes/macrophages.

Original languageEnglish
Pages (from-to)188-206
Number of pages19
JournalBlood Purification
Volume6
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • Cell walls
  • Complement
  • Endotoxin
  • Interleukin-1
  • Lipid A
  • Lipopolysaccharides
  • Macrophages
  • Monocytes
  • Muramylpeptides
  • Peptidoglycans

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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