Abstract
A variety of compounds, synthetic, semisynthetic or bacterial, which corre-sponds to structural components of endotoxic lipopolysaccharides (LPS) and bacterial cell wall peptidoglycans were studied for their activity to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production by macrophages and activated the human complement cascade, which may lead to the IL-1 production by monocytes/macrophages.
Original language | English |
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Pages (from-to) | 188-206 |
Number of pages | 19 |
Journal | Blood Purification |
Volume | 6 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1988 |
Externally published | Yes |
Keywords
- Cell walls
- Complement
- Endotoxin
- Interleukin-1
- Lipid A
- Lipopolysaccharides
- Macrophages
- Monocytes
- Muramylpeptides
- Peptidoglycans
ASJC Scopus subject areas
- Hematology
- Nephrology