Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1

Ichiro Takahashi; Shozo Kotani; Haruhiko Takada; Teisuo Shiba; Shoichi Kusumoto

doi:10.1159/000169545

Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1

Ichiro Takahashi, Shozo Kotani, Haruhiko Takada, Teisuo Shiba, Shoichi Kusumoto

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A variety of compounds, synthetic, semisynthetic or bacterial, which corre-sponds to structural components of endotoxic lipopolysaccharides (LPS) and bacterial cell wall peptidoglycans were studied for their activity to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production by macrophages and activated the human complement cascade, which may lead to the IL-1 production by monocytes/macrophages.

Original language	English
Pages (from-to)	188-206
Number of pages	19
Journal	Blood Purification
Volume	6
Issue number	3
DOIs	https://doi.org/10.1159/000169545
Publication status	Published - 1988

Keywords

Cell walls
Complement
Endotoxin
Interleukin-1
Lipid A
Lipopolysaccharides
Macrophages
Monocytes
Muramylpeptides
Peptidoglycans

ASJC Scopus subject areas

Hematology
Nephrology

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abstract = "A variety of compounds, synthetic, semisynthetic or bacterial, which corre-sponds to structural components of endotoxic lipopolysaccharides (LPS) and bacterial cell wall peptidoglycans were studied for their activity to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production by macrophages and activated the human complement cascade, which may lead to the IL-1 production by monocytes/macrophages.",

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AU - Takahashi, Ichiro

AU - Kotani, Shozo

AU - Takada, Haruhiko

AU - Shiba, Teisuo

AU - Kusumoto, Shoichi

PY - 1988

Y1 - 1988

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Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1

Abstract

Keywords

ASJC Scopus subject areas

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