Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity

Haruhisa Kikuchi, Kazunori Sasaki, Jun'ichi Sekiya, Yasuo Maeda, Aiko Amagai, Yuzuru Kubohara, Yoshiteru Oshima

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Cellular slime molds are fascinating to the field of developmental biology, and have long been used as excellent model organisms for the study of various aspects of multicellular development. We have recently isolated α-pyronoids, named dictyopyrones A-D (1-4), from various species of Dictyostelium cellular slime molds, and it was shown that compound 3 may regulate Dictyostelium development. In this study, we synthesized dictyopyrones A-D (1-4) and their analogues, investigated the physiological role of the molecules in cell growth and morphogenesis in D. discoideum, and further verified their effects on human leukemia K562 cells. Nitrogen-containing compounds 22 and 37 strongly inhibited cell growth in K562 leukemia cells, indicating that these compounds may be utilized as novel lead compounds for anti-leukemic agents.

Original languageEnglish
Pages (from-to)3203-3214
Number of pages12
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number12
DOIs
Publication statusPublished - 2004 Jun 15

Keywords

  • Anti-leukemic activity
  • Cellular slime molds
  • Dictyostelium discoideum
  • α-pyrone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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