Structural insights into differences in G protein activation by family A and family B GPCRs

Daniel Hilger; Kaavya Krishna Kumar; Hongli Hu; Mie Fabricius Pedersen; Evan S. O'Brien; Lise Giehm; Christine Jennings; Gözde Eskici; Asuka Inoue; Michael Lerch; Jesper Mosolff Mathiesen; Georgios Skiniotis; Brian K. Kobilka

doi:10.1126/science.aba3373

Structural insights into differences in G protein activation by family A and family B GPCRs

Daniel Hilger, Kaavya Krishna Kumar, Hongli Hu, Mie Fabricius Pedersen, Evan S. O'Brien, Lise Giehm, Christine Jennings, Gözde Eskici, Asuka Inoue, Michael Lerch, Jesper Mosolff Mathiesen, Georgios Skiniotis, Brian K. Kobilka

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Comment/debate › peer-review

40 Citations (Scopus)

Original language	English
Journal	Science
Volume	369
Issue number	6503
DOIs	https://doi.org/10.1126/science.aba3373
Publication status	Published - 2020 Jul 31

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@article{500b9eb01ab3434898171edd7c48f3e5,

title = "Structural insights into differences in G protein activation by family A and family B GPCRs",

author = "Daniel Hilger and Kumar, {Kaavya Krishna} and Hongli Hu and Pedersen, {Mie Fabricius} and O'Brien, {Evan S.} and Lise Giehm and Christine Jennings and G{\"o}zde Eskici and Asuka Inoue and Michael Lerch and Mathiesen, {Jesper Mosolff} and Georgios Skiniotis and Kobilka, {Brian K.}",

note = "Funding Information: D.H. was supported by the German Academic Exchange Service (DAAD). K.K.K. was supported by the American Diabetes Association (ADA) Postdoctoral Fellowship. A.I. was funded by the PRIME 18 g5910013 from the Japan Agency for Medical Research and Development (AMED) and the Japan Society for the Promotion of Science (JSPS) KAKENHI 17K08264. The work is supported by NIH grants R01GM083118 and R01NS028471 to B.K.K.; B.K.K. is a Chan Zuckerberg Biohub investigator.",

year = "2020",

month = jul,

day = "31",

doi = "10.1126/science.aba3373",

language = "English",

volume = "369",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6503",

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TY - JOUR

T1 - Structural insights into differences in G protein activation by family A and family B GPCRs

AU - Hilger, Daniel

AU - Kumar, Kaavya Krishna

AU - Hu, Hongli

AU - Pedersen, Mie Fabricius

AU - O'Brien, Evan S.

AU - Giehm, Lise

AU - Jennings, Christine

AU - Eskici, Gözde

AU - Inoue, Asuka

AU - Lerch, Michael

AU - Mathiesen, Jesper Mosolff

AU - Skiniotis, Georgios

AU - Kobilka, Brian K.

N1 - Funding Information: D.H. was supported by the German Academic Exchange Service (DAAD). K.K.K. was supported by the American Diabetes Association (ADA) Postdoctoral Fellowship. A.I. was funded by the PRIME 18 g5910013 from the Japan Agency for Medical Research and Development (AMED) and the Japan Society for the Promotion of Science (JSPS) KAKENHI 17K08264. The work is supported by NIH grants R01GM083118 and R01NS028471 to B.K.K.; B.K.K. is a Chan Zuckerberg Biohub investigator.

PY - 2020/7/31

Y1 - 2020/7/31

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UR - http://www.scopus.com/inward/citedby.url?scp=85088884640&partnerID=8YFLogxK

U2 - 10.1126/science.aba3373

DO - 10.1126/science.aba3373

M3 - Comment/debate

C2 - 32732395

AN - SCOPUS:85088884640

VL - 369

JO - Science

JF - Science

SN - 0036-8075

IS - 6503

ER -

Structural insights into differences in G protein activation by family A and family B GPCRs

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