Structural diversity of new C13-polyketides produced by Chaetomium mollipilium cultivated in the presence of a NAD+-dependent histone deacetylase inhibitor

Teigo Asai, Shuntaro Morita, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Hiroaki Sakurai, Tomoji Ozeki, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Cultivation of Chaetomium mollipilium with nicotinamide, a NAD +-dependent HDAC inhibitor, stimulated its secondary metabolism, leading to the isolation of structurally diverse new C13-polyketides, mollipilin A-E (1-5) as well as two known compounds (6 and 7). Spectroscopic methods, X-ray single crystal diffraction analysis, and VCD elucidated the absolute configurations of structures 1-6, and plausible biosynthetic pathways for 1-7 were proposed based on structural relationships. Mollipilins A (1) and B (2) exhibited moderate growth inhibitory effects on HCT-116 cells.

Original languageEnglish
Pages (from-to)5456-5459
Number of pages4
JournalOrganic letters
Volume14
Issue number21
DOIs
Publication statusPublished - 2012 Nov 2

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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