Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.
- 1′-acetoxychavicol acetate
- Benzhydrol analog
- Molecular operating environment
- Quantitative structure-activity relationship
ASJC Scopus subject areas
- Drug Discovery