Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa, Hiroshi Aoyama, Taniyuki Furuyama, Kosuke Dodo, Morihiko Sagawa, Hiroyuki Miyachi, Masahiro Kizaki, Yuichi Hashimoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.

Original languageEnglish
Pages (from-to)1490-1495
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number10
DOIs
Publication statusPublished - 2008 Oct 1

Keywords

  • 1′-acetoxychavicol acetate
  • Benzhydrol analog
  • HL-60
  • Molecular operating environment
  • Quantitative structure-activity relationship

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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