Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides

Haruhiko Takada, Yoshihiro Kawabata, Shigeo Kawata, Shoichi Kusumoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Structural characteristics of peptidoglycan fragments required to prime mice for the induction of anaphylactoid reactions by Salmonella abortusequi lipopolysaccharide were examined in endotoxin-resistant C3H/HeJ mice, with special focus on the disaccharide-pentapeptide [N-acetylglucosaminyl-β(1- 4)-N-acetylmuramyl-L-alanyl-D-isoglutaminyl-meso-2,6-diaminopimelyl (DAP)-D- alanyl-D-alanine] and its smaller partial derivatives. The bacterial and synthetic muramyl tripeptides (DAP- and lysine [Lys]-type, respectively) and synthetic muramyl dipeptide primed mice for induction of anaphylactoid reactions accompanied by death within 1 h. The disaccharide-tripeptide exhibited weaker activity, and the disaccharide-tetrapeptide and muramyl tetrapeptide exhibited marginal activity. In contrast, intact peptidoglycans of various bacteria and the disaccharide-pentapeptide lacked the priming activity, although they showed adjuvant activity similar to that of the above components.

Original languageEnglish
Pages (from-to)657-659
Number of pages3
JournalInfection and immunity
Volume64
Issue number2
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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