Structural basis for a Ca2+-Sensing functions of the metabotropic glutamate receptors

Yoshihiro Kubo, Tomoyuki Miyashita, Yoshimichi Murata

Research output: Contribution to journalArticlepeer-review

190 Citations (Scopus)


The metabotropic glutamate receptors (mGluRs) are widely distributed in the brain and play important roles in synaptic plasticity. Here it is shown that some types of mGluRs are activated not only by glutamate but also by extracellular Ca2+ (Ca2+(o)). A single amino acid residue was found to determine the sensitivity of mGluRs to Ca2+(o). One of the receptors, mGluR1α, but not its point mutant with reduced sensitivity to Ca2+(o), caused morphological changes when transfected into mammalian cells. Thus, the sensing of Ca2+(o) by mGluRs may be important in cells under physiological condition.

Original languageEnglish
Pages (from-to)1722-1725
Number of pages4
Issue number5357
Publication statusPublished - 1998 Mar 13
Externally publishedYes

ASJC Scopus subject areas

  • General


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