Structural and functional diversities of the Aplysia Mytilus inhibitory peptide-related peptides

Kosei Sasaki, Yoriko Shimizu, Genbu Abe, Yuko Fujisawa, Fumihiro Morishita, Osamu Matsushima, Yasuo Furukawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Aplysia Mytilus inhibitory peptide-related peptides (AMRPs) are multiple hexapeptides coded on a single precursor. By comparing the AMRP precursors of two species of Aplysia (Aplysia californica and Aplysia kurodai), we found that there are substantial numbers of species-specific AMRPs. We next compared the function of AMRPs on the anterior aorta between A. kurodai and Aplysia juliana. In A. juliana, AMRPs inhibited the contractile activity of the aorta (EC50=10-9 to 10-8M), whereas the peptides had no obvious action in A. kurodai up to 10-7M. These results indicate that AMRPs are both structurally and functionally diverse neuropeptides even among closely related species.

Original languageEnglish
Pages (from-to)1959-1965
Number of pages7
JournalPeptides
Volume23
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Keywords

  • Anterior aorta
  • Aplysia
  • Immunohistochemistry
  • Neuropeptide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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