Strict preparation and evaluation of water-soluble hat-stacked carbon nanofibers for biomedical application and their high biocompatibility: Influence of nanofiber-surface functional groups on cytotoxicity

Yoshinori Sato, Ken Ichiro Shibata, Hideo Kataoka, Shin Ichi Ogino, Fugetsu Bunshi, Atsuro Yokoyama, Kazuchika Tamura, Tsukasa Akasaka, Motohiro Uo, Kenichi Motomiya, Balachandran Jeyadevan, Rikizo Hatakeyama, Fumio Watari, Kazuyuki Tohji

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Water-soluble H-CNFs modified with a carboxyl group possessed the ability to induce TNF-α, whereas CHAPS-treated H-CNFs possessed significantly greater activity and were also found to activate NF-κB reporter activity, to a significantly greater level than H-CNFs; furthermore the functional group modified or coated on the surface of H-CNFs was a significant cytotoxic factor that affected cell activation.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalMolecular BioSystems
Volume1
Issue number2
DOIs
Publication statusPublished - 2005 Dec 1

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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    Sato, Y., Shibata, K. I., Kataoka, H., Ogino, S. I., Bunshi, F., Yokoyama, A., Tamura, K., Akasaka, T., Uo, M., Motomiya, K., Jeyadevan, B., Hatakeyama, R., Watari, F., & Tohji, K. (2005). Strict preparation and evaluation of water-soluble hat-stacked carbon nanofibers for biomedical application and their high biocompatibility: Influence of nanofiber-surface functional groups on cytotoxicity. Molecular BioSystems, 1(2), 142-145. https://doi.org/10.1039/b501222h