TY - JOUR
T1 - Stress signaling in cancer
AU - Murakami, Shiori
AU - Noguchi, Takuya
AU - Takeda, Kohsuke
AU - Ichijo, Hidenori
PY - 2007/10
Y1 - 2007/10
N2 - The human body is continuously exposed to a wide variety of physical, chemical, and biological stress stimuli from both the external and internal environments. In order to adapt to or resist stress, cells are equipped with multiple signaling systems, which elicit a wide range of stress responses. Stress signaling also operates to eliminate cells with severe stress-induced damage through the induction of apoptosis. Once stress signaling is compromised in certain adverse conditions, however, cells exhibit aberrant responses to stress, which can eventually cause various diseases including cancer. In the present review, the authors focus on the current understanding of the critical linkage between stress signaling and cancer.
AB - The human body is continuously exposed to a wide variety of physical, chemical, and biological stress stimuli from both the external and internal environments. In order to adapt to or resist stress, cells are equipped with multiple signaling systems, which elicit a wide range of stress responses. Stress signaling also operates to eliminate cells with severe stress-induced damage through the induction of apoptosis. Once stress signaling is compromised in certain adverse conditions, however, cells exhibit aberrant responses to stress, which can eventually cause various diseases including cancer. In the present review, the authors focus on the current understanding of the critical linkage between stress signaling and cancer.
UR - http://www.scopus.com/inward/record.url?scp=34548181620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548181620&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.2007.00551.x
DO - 10.1111/j.1349-7006.2007.00551.x
M3 - Review article
C2 - 17645775
AN - SCOPUS:34548181620
VL - 98
SP - 1521
EP - 1527
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 10
ER -