Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets

Hiroshi Yamamoto; Yasuko Uchigata; Hiroshi Okamoto

doi:10.1038/294284a0

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets

Hiroshi Yamamoto, Yasuko Uchigata, Hiroshi Okamoto

Research output: Contribution to journal › Article › peer-review

459 Citations (Scopus)

Abstract

Streptozotocin, which produces diabetes mellitus in experimental animals^1-3, has been reported to reduce the level of NAD in pancreatic islets^4,5 and to inhibit islet synthesis of proinsulin⁶. The decrease in NAD is due to increased NAD degradation mediated by islet nuclear poly(ADP-ribose) synthetase^7,8. Evidence suggests that poly(ADP-ribose) synthetase is activated when DNA is fragmented^9-17. Here we describe that both Streptozotocin and alloxan, which also produces experimental diabetes mellitus^1,2, cause DNA strand breaks which stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.

Original language	English
Pages (from-to)	284-286
Number of pages	3
Journal	Nature
Volume	294
Issue number	5838
DOIs	https://doi.org/10.1038/294284a0
Publication status	Published - 1981 Dec 1
Externally published	Yes

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title = "Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets",

abstract = "Streptozotocin, which produces diabetes mellitus in experimental animals1-3, has been reported to reduce the level of NAD in pancreatic islets4,5 and to inhibit islet synthesis of proinsulin6. The decrease in NAD is due to increased NAD degradation mediated by islet nuclear poly(ADP-ribose) synthetase7,8. Evidence suggests that poly(ADP-ribose) synthetase is activated when DNA is fragmented9-17. Here we describe that both Streptozotocin and alloxan, which also produces experimental diabetes mellitus1,2, cause DNA strand breaks which stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.",

author = "Hiroshi Yamamoto and Yasuko Uchigata and Hiroshi Okamoto",

year = "1981",

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doi = "10.1038/294284a0",

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journal = "Nature",

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T1 - Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets

AU - Yamamoto, Hiroshi

AU - Uchigata, Yasuko

AU - Okamoto, Hiroshi

PY - 1981/12/1

Y1 - 1981/12/1

N2 - Streptozotocin, which produces diabetes mellitus in experimental animals1-3, has been reported to reduce the level of NAD in pancreatic islets4,5 and to inhibit islet synthesis of proinsulin6. The decrease in NAD is due to increased NAD degradation mediated by islet nuclear poly(ADP-ribose) synthetase7,8. Evidence suggests that poly(ADP-ribose) synthetase is activated when DNA is fragmented9-17. Here we describe that both Streptozotocin and alloxan, which also produces experimental diabetes mellitus1,2, cause DNA strand breaks which stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.

AB - Streptozotocin, which produces diabetes mellitus in experimental animals1-3, has been reported to reduce the level of NAD in pancreatic islets4,5 and to inhibit islet synthesis of proinsulin6. The decrease in NAD is due to increased NAD degradation mediated by islet nuclear poly(ADP-ribose) synthetase7,8. Evidence suggests that poly(ADP-ribose) synthetase is activated when DNA is fragmented9-17. Here we describe that both Streptozotocin and alloxan, which also produces experimental diabetes mellitus1,2, cause DNA strand breaks which stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.

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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets

Abstract

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