Strategies for the synthesis of 2-substituted indoles and indolines starting from acyclic α-phosphoryloxy enecarbamates

Haruhiko Fuwa, Makoto Sasaki

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Strategies have been developed for the synthesis of 2-substituted indoles and indolines starting from acyclic α-phosphoryloxy enecarbamates. A highly chemoselective cross-coupling of N-(o-bromophenyl)-α- phosphoryloxyenecarbamates with boron nucleophiles enabled the efficient preparation of various N-(o-bromophenyl)enecarbamates, which served as useful precursors for subsequent Heck-type cyclization or 5-endo-trig aryl radical cyclization to furnish 2-substituted indoles or indolines, respectively.

Original languageEnglish
Pages (from-to)3347-3350
Number of pages4
JournalOrganic letters
Volume9
Issue number17
DOIs
Publication statusPublished - 2007 Aug 16

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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