Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin

    Research output: Contribution to journalReview article

    3 Citations (Scopus)

    Abstract

    Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all-carbon macrocyclic skeleton. To the date, seven total syntheses, two formal total syntheses and a number of synthetic studies on this hot molecule have been reported. In this short review article, we mainly survey and comment on these efforts regarding the difficult macrocyclization strategies.

    Original languageEnglish
    Pages (from-to)203-212
    Number of pages10
    JournalJournal of Antibiotics
    Volume69
    Issue number4
    DOIs
    Publication statusPublished - 2016 Apr 1

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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