Stimulation of Titanium Implant Osseointegration Through High-Frequency Vibration Loading is Enhanced when Applied at High Acceleration

Toru Ogawa, Katleen Vandamme, Xiaolei Zhang, Ignace Naert, Tine Possemiers, Amol Chaudhari, Keiichi Sasaki, Joke Duyck

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Low-magnitude high-frequency loading, applied by means of whole body vibration (WBV), affects the bone. Deconstructing a WBV loading stimulus into its constituent elements and investigating the effects of frequency and acceleration individually on bone tissue kinetics around titanium implants were aimed for in this study. A titanium implant was inserted in the tibia of 120 rats. The rats were divided into 1 control group (no loading) and 5 test groups with low (L), medium (M) or high (H) frequency ranges and accelerations [12–30 Hz at 0.3×g (FLAH); 70–90 Hz at 0.075×g (FMAM); 70–90 Hz at 0.3×g (FMAH); 130–150 Hz at 0.043×g (FHAL); 130–150 Hz at 0.3×g (FHAH)]. WBV was applied for 1 or 4 weeks. Implant osseointegration was evaluated by quantitative histology (bone-to-implant contact (BIC) and peri-implant bone formation (BV/TV)). A 2-way ANOVA (duration of experimental period; loading mode) with α = 0.05 was performed. BIC significantly increased over time and under load (p < 0.0001). The highest BICs were found for loading regimes at high acceleration with medium or high frequency (FMAH and FHAH), and significantly differing from FLAH and FMAM (p < 0.02 and p < 0.005 respectively). BV/TV significantly decreased over time (p < 0.0001). Loading led to a site-specific BV/TV increase (p < 0.001). The highest BV/TV responses were found for FMAH and FHAH, significantly differing from FMAM (p < 0.005). The findings reveal the potential of high-frequency vibration loading to accelerate and enhance implant osseointegration, in particular when applied at high acceleration. Such mechanical signals hold great, though untapped, potential to be used as non-pharmacologic treatment for improving implant osseointegration in compromised bone.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalCalcified Tissue International
Volume95
Issue number5
DOIs
Publication statusPublished - 2014 Oct 8

Keywords

  • Acceleration
  • Frequency
  • Rat tibia
  • Titanium implant osseointegration
  • Whole body vibration

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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