Abstract
Sigma-1 receptor (Sig-1R) is molecular chaperone regulating calcium efflux from the neuronal endoplasmic reticulum to mitochondria. Recent studies show that Sig-1R stimulation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII/CaMKIV and protein kinase B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII/CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation.
Original language | English |
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Pages (from-to) | 201-211 |
Number of pages | 11 |
Journal | Advances in experimental medicine and biology |
Volume | 964 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- BDNF
- CaMKII
- CaMKIV
- Depression
- Neurogenesis
- Sigma-1 receptor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)