Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity

Arno R.N. Donfack, Ngeh J. Toyang, Hippolyte K. Wabo, Pierre Tane, Maurice D. Awouafack, Haruhisa Kikuchi, Jean D.D. Tamokou, Jules R. Kuiate, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH 2Cl 2-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.

Original languageEnglish
Pages (from-to)596-599
Number of pages4
JournalPhytochemistry Letters
Volume5
Issue number3
DOIs
Publication statusPublished - 2012 Sep

Keywords

  • Antimicrobial activity
  • Asteraceae
  • Stigmastane derivatives
  • Vernoguinoside A
  • Vernonia guineensis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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