Sticking It to Cancer with Molecular Glue for SHP2

Hao Ran, Ryouhei Tsutsumi, Toshiyuki Araki, Benjamin G. Neel

Research output: Contribution to journalShort surveypeer-review

44 Citations (Scopus)


Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.

Original languageEnglish
Pages (from-to)194-196
Number of pages3
JournalCancer Cell
Issue number2
Publication statusPublished - 2016 Aug 8
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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