Steroid sulfatase inhibitors: Promising new tools for breast cancer therapy?

Jürgen Geisler, Hironobu Sasano, Shiuan Chen, Atul Purohit

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Inhibition of aromatase is currently well-established as the major treatment option of hormone-dependent breast cancer in postmenopausal women. However, despite the effects of aromatase inhibitors in both early and metastatic breast cancer, endocrine resistance may cause relapses of the disease and progression of metastasis. Thus, driven by the success of manipulating the steroidogenic enzyme aromatase, several alternative enzymes involved in steroid synthesis and metabolism have recently been investigated as possible drug targets. One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively. Estrone and DHEA may thereafter be used for the synthesis of more potent estrogens and androgens that may eventually fuel hormone-sensitive breast cancer cells. The present review summarizes the biology behind steroid sulfatase and its inhibition, the currently available information derived from basic and early clinical trials in breast cancer patients, as well as ongoing research. Article from the Special Issue on Targeted Inhibitors.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume125
Issue number1-2
DOIs
Publication statusPublished - 2011 May 1

Keywords

  • Androgens
  • Aromatase inhibitors
  • Breast cancer
  • Estrogens
  • Irosustat
  • STX 213
  • STX 64
  • STX 681
  • Sulfatase inhibitors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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