Steroid sulfatase and estrogen sulfotransferase in human prostate cancer

Yasuhiro Nakamura, Takashi Suzuki, Tsuyoshi Fukuda, Akihiro Ito, Mareyuki Endo, Takuya Moriya, Yoichi Arai, Hironobu Sasano

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

BACKGROUND. Estrogen sulfotransferase (EST) and steroid sulfatase (STS) are known to be involved in in situ estrogen production in estrogen dependent human cancer such as breast cancer, but unknown in prostate cancer. MATERIALS AND METHODS. We first examined whether these enzymes above were expressed and actually involved in estrogen production and metabolism in prostate cancer cell lines (LNCaP, DU-145, and PC-3). We than examined the expression of EST and STS in human prostate cancer tissues obtained from surgery (n = 52) using immunohistochemistry. RESULTS. mRN As of both enzymes were detected in all prostate cancer cell lines examined, and the synthesis of estrone (E 1) and estradiol (E2) was also confirmed in these cell lines. In addition, STS immunoreactivity was detected in 44 cases (85%) and EST in 39 cases (75%), respectively. CONCLUSIONS. STS and EST are expressed and may be involved in local production and metabolism of estrogens in human prostate cancers.

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalProstate
Volume66
Issue number9
DOIs
Publication statusPublished - 2006 Jun 15

Keywords

  • Cell lines
  • Estrogen sulfotransferase
  • Immunohistochemistry
  • Prostate cancer
  • Steroid sulfatase

ASJC Scopus subject areas

  • Oncology
  • Urology

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