Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer

Xiaoni Yue, Jun Ichi Akahira, Hiroki Utsunomiya, Yasuhiro Miki, Naomi Takahashi, Hitoshi Niikura, Kiyoshi Ito, Hironobu Sasano, Kunihiro Okamura, Nobuo Yaegashi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We examined the expression of the steroid and xenobiotic receptor (SXR) and evaluated its clinical significance in human epithelial ovarian carcinoma. One hundred forty-one cases were examined using immunohistochemistry for SXR with archival specimens. All cases were scored using a semi-quantitative histological scoring (HSCORE) method. Specimens with an HSCORE > 60 were regarded as SXR-positive. Various clinicopathologic variables were examined. SXR showed significant differences in age, histology, grade, ERα and PR. SXR was detected in 35 of 141 (24.8%) ovarian cancer tissues. There was a statistically significant negative correlation between SXR-positive status and both disease-free survival and overall survival (P = 0.0415 and 0.0316, respectively), independent of stage (P = 0.0167 and 0.021, respectively). In multivariate analysis, SXR was a statistically independent risk factor for both disease-free survival and overall survival (P = 0.049 and 0.0354). Our results support an association of SXR between ERα and PR in epithelial ovarian cancers. Our data suggest that SXR is a prognostic factor in epithelial ovarian cancer and may represent a useful marker to identify patients at risk of recurrence or death.

Original languageEnglish
Pages (from-to)400-406
Number of pages7
JournalPathology international
Volume60
Issue number5
DOIs
Publication statusPublished - 2010 May
Externally publishedYes

Keywords

  • Histological scoring (HSCORE)
  • Immunohistochemistry
  • Ovarian cancer
  • Steroid and xenobiotic receptor (SXR)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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