Sterically congested ester formation from α-substituted malononitrile and alcohol by an oxidative method using molecular oxygen

Yujiro Hayashi, Jing Li, Hirotaka Asano, Daisuke Sakamoto

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A metal-free oxidative esterification or thio-esterifica-tion of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.

Original languageEnglish
Pages (from-to)675-677
Number of pages3
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number4
DOIs
Publication statusPublished - 2019 Jan 31

Keywords

  • Esterification
  • Esters
  • Malononitrile
  • Oxygen
  • Steric hindrance

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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