Sterically congested ester formation from α-substituted malononitrile and alcohol by an oxidative method using molecular oxygen

Yujiro Hayashi; Jing Li; Hirotaka Asano; Daisuke Sakamoto

doi:10.1002/ejoc.201800984

Sterically congested ester formation from α-substituted malononitrile and alcohol by an oxidative method using molecular oxygen

Yujiro Hayashi, Jing Li, Hirotaka Asano, Daisuke Sakamoto

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A metal-free oxidative esterification or thio-esterifica-tion of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.

Original language	English
Pages (from-to)	675-677
Number of pages	3
Journal	European Journal of Organic Chemistry
Volume	2019
Issue number	4
DOIs	https://doi.org/10.1002/ejoc.201800984
Publication status	Published - 2019 Jan 31
Externally published	Yes

Keywords

Esterification
Esters
Malononitrile
Oxygen
Steric hindrance

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1002/ejoc.201800984

Cite this

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abstract = "A metal-free oxidative esterification or thio-esterifica-tion of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.",

keywords = "Esterification, Esters, Malononitrile, Oxygen, Steric hindrance",

author = "Yujiro Hayashi and Jing Li and Hirotaka Asano and Daisuke Sakamoto",

note = "Funding Information: This work was funded by JSPS 16K13942. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

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AU - Hayashi, Yujiro

AU - Li, Jing

AU - Asano, Hirotaka

AU - Sakamoto, Daisuke

PY - 2019/1/31

Y1 - 2019/1/31

N2 - A metal-free oxidative esterification or thio-esterifica-tion of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.

AB - A metal-free oxidative esterification or thio-esterifica-tion of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α-substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.

KW - Esterification

KW - Esters

KW - Malononitrile

KW - Oxygen

KW - Steric hindrance

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SN - 0075-4617

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ER -

Sterically congested ester formation from α-substituted malononitrile and alcohol by an oxidative method using molecular oxygen

Abstract

Keywords

ASJC Scopus subject areas

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