Stereotactic radiotherapy for lung cancer using active breathing control system

Kenji Takai, Yoshihiro Takai, Masashi Koto, Masatoshi Mitsuya, Ken Takeda, Kenji Nemoto, Yoshihiro Ogawa, Tohru Sakayauchi, Toshiyuki Sugawara, Shogo Yamada

Research output: Contribution to journalArticlepeer-review

Abstract

In Tohoku University Hospital, primary or metastatic lung cancers with the respiratory motion of more than 1 cm were treated with SRT (stereotactic radiotherapy) under ABC (active breathing control: ABC-SRT). The local control rate and lung toxicity treated with ABC-SRT were analyzed. The indication of ABC-SRT is as follows: tumor size in largest diameter ≦5 cm, motion distance ≧1 cm, and patient's consent to treatment. Nineteen patients (average age: 58.2 years, male 12: female 7) with 25 lesions were enrolled to ABC-SRT during March 2000 and July 2004. Patients with primary lung cancer were four, the others with metastatic cancer. Prescribed doses were 45 Gy/3 fr or 60 Gy/8 fr at the isocenter. ABC-SRT was successfully done for all patients except one patient who failed to be given the prescribed dose (only 45 Gy/6 fr were administered). In 24 lesions with complete treatment, the control rate in 1/2/4 years was 94.1%/74.0%/74.0%, respectively. In tumors <2.5 cm size in largest diameter, the control rate was 90.0%, ≧2.5 cm, 42.9%, tendency of significance (p=0.0579) was observed. One patient developed grade 2 pneumonitis (RTOG: Radiation Therapy Oncologic Group/EORTC: European Organization for Research and Treatment of Cancer), who was then orally medicated with steroid to cure. The others developed grade 0-1 pneumonitis. Although 10 of 19 patients were treated with chemotherapy, the lung toxicity was relatively light. Reduction of PTV by ABC seem to reduce the lung toxicity. In tumors <2.5 cm size in largest diameter, good control rate was acquired compared to the tumors ≧ 2.5 cm in size. We're going to analyze the lung toxicity treated without ABC-SRT to compare the present results.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalJournal of JASTRO
Volume18
Issue number2
Publication statusPublished - 2006 Jun 1

Keywords

  • Active breathing control
  • Lung cancer
  • Lung toxicity
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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