Stereotactic radiosurgery followed by whole ventricular irradiation for primary intracranial germinoma of the pineal region

H. Endo, Toshihiro Kumabe, H. Jokura, T. Tominaga

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Intracranial germinomas can be cured by radiotherapy and/or chemotherapy. Three patients with pineal germinoma were treated with stereotactic radiosurgery using the gamma knife (10-12 Gy) to the tumors followed by whole ventricular irradiation (24 Gy). All patients had solitary pineal tumor measuring less than 3 cm, clinically compatible with germinoma, normal cerebrospinal fluid (CSF) and serum levels of alpha-fetoprotein and beta-human chorionic gonadotropin, no disseminated disease on spinal magnetic resonance (MR) imaging, and no abnormal CSF cytology. All patients showed complete response to the combined radiotherapy, and MR imaging has shown no recurrence of the tumor. Combined radiotherapy using gamma knife radiosurgery is effective for pineal germinoma, and reduced the cost of treatment with less need for hospitalization.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalMinimally Invasive Neurosurgery
Volume48
Issue number3
DOIs
Publication statusPublished - 2005 Jun

Keywords

  • Gamma knife
  • Hospitalization period
  • Pineal germinoma
  • Treatment cost

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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