Stereoselective synthesis of the left wing of Caribbean ciguatoxin

Shuji Yamashita, Ryohei Uematsu, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are potent toxic polycyclic ethers. In this paper, we report a stereoselective and secure route to the left wing of Caribbean ciguatoxin on the basis of a 6-exo radical cyclization strategy.

Original languageEnglish
Pages (from-to)6616-6626
Number of pages11
Issue number35
Publication statusPublished - 2011 Sep 2
Externally publishedYes


  • Caribbean ciguatoxin
  • Convergent synthesis
  • Polycyclic ether
  • Radical cyclization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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