Stereoselective synthesis of the CDE ring system of antitumor saponin scillascilloside E-1

Yoshihiro Akahori, Hiroyuki Yamakoshi, Shunichi Hashimoto, Seiichi Nakamura

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A stereoselective synthesis of the CDE ring portion of the antitumor saponin scillascilloside E-1 has been achieved, utilizing an Ireland-Claisen rearrangement to construct the contiguous tetrasubstituted stereocenters at C13 and C17 simultaneously and intramolecular nitrile oxide cycloaddition to form the five-membered ring as key steps.

Original languageEnglish
Pages (from-to)2054-2057
Number of pages4
JournalOrganic letters
Volume16
Issue number7
DOIs
Publication statusPublished - 2014 Apr 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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